BD²: Breakthrough Discoveries for thriving with Bipolar Disorder funds science in search of ways to help every person with bipolar disorder thrive. We seek multidisciplinary teams to collaborate and explore the fundamental mechanisms, heterogeneity, progression, and underlying biology of the disorder to dramatically improve systems of care and accelerate research.

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Since launch, BD² has invested $60M+ in research commitments.

Funding Opportunities:
Requests for Applications (RFAs)

Showing 7 of 7 results.
Title Description Amount Year/Status RFA Links
Discovery Research
Discovery Research, Cycle 2

The Discovery Research program supports an innovative and collaborative group of researchers working together to improve our understanding of the biological mechanisms that underlie bipolar disorder. We seek multidisciplinary teams of scientists to develop targeted and groundbreaking research applications that will examine the genetic, molecular, cellular, circuit, and/or behavioral mechanisms of bipolar disorder.

Amount: up to $4,500,000
over 3 years
Year/Status: 2023Open Now Download RFA FAQ
Integrated Network
BD² Integrated Network Clinical Coordinating Center (CCC)

As part of the BD² Integrated Network, the CCC provides expert guidance and logistical support including key diagnostics and clinical assessments, Institutional Review Board activities, a rigorous study monitoring plan, and coordination of clinical care activities.

Amount: up to $5,400,000
over 5 years
Year/Status: 2022Inactive Download RFA
Integrated Network
BD² Integrated Network Data Coordinating Center & Centralized Repository (DCC)

As part of the BD² Integrated Network, the DCC provides technical and logistical support for iterative cycles of data aggregation, analyses, and implementation.

Amount: up to $5,000,000
over 5 years
Year/Status: 2022Inactive Download RFA
Integrated Network
BD² Integrated Network Site

In partnership with people living with bipolar disorder, clinicians, and researchers, the BD² Integrated Network brings together a community committed to dramatically improving systems of care and accelerating research. Integrated Network sites make up a learning health network (LHN) with the goal of rapid integration of data analytics from research to inform clinical care.

Amount: $2,250,000
over 5 years
Year/Status: 2022Inactive Download RFA
Brain Omics Platform
Brain Omics Platform

The Brain Omics Platform analyzes a variety of epigenetic, transcriptomic, proteomic, and other omic characteristics of human brain tissue from people with bipolar disorder. Our partners conduct state-of-the-art research to develop the molecular atlas of neural and non-neural changes in people with bipolar disorder.

Amount: up to $5,000,000
for up to 3 years
Year/Status: 2022Inactive Download RFA
Discovery Research
Discovery Research, Cycle 1

The Discovery Research program aims to delineate the causal mechanisms of bipolar disorder. The network of interdisciplinary researchers strategically advance our understanding of bipolar disorder and accelerate the development of effective interventions. Funded teams share resources, data, and progress with other teams in the network throughout the funding period.

Amount: up to $4,500,000
over 3 years
Year/Status: 2022Inactive Download RFA
Genetics Platform
Genetics Platform

The Genetics Platform advances our understanding of bipolar disorder genetics, including nuclear and mitochondrial genetics. Our partners collect and genotype an unprecedented quantity and diversity of samples from people with bipolar disorder to decode the complex genetic architecture of the disorder.

Amount: up to $10,000,000
over 2 years
Year/Status: 2022Inactive Download RFA