Our approach combines the power of discovery with accelerated translation of findings to care by generating data collected in real-world clinical settings alongside a comprehensive longitudinal research study.

The Model

Recognizing an urgent need to drive progress in bipolar disorder research and care, BD² is bringing together an unprecedented depth of information from people with bipolar disorder to effectively lift the ceiling on current scientific understanding, create new treatment options, and drive a path towards wellness.

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About the Integrated Network

This initiative will connect thousands of participants and their care teams to a network of experts, allowing for real-time collaboration between study participants, scientists, and clinicians. The shared information and knowledge from this collaboration have the potential to drive discovery in bipolar disorder in a way that has never been done before in mental health or neuroscience.

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Our Network

By learning more about participants’ daily lives and connecting them with clinicians and researchers who share data across sites, we will accelerate what we can learn about the biology of bipolar disorder, determine biologically defined subtypes, and provide a scientific basis for new, targeted treatments. The inaugural cohort of clinical sites comprises six institutions with proven track records of excellence in bipolar disorder treatment.

Study Design icon

Study Design

Our model interweaves a longitudinal cohort study, engaging people with bipolar disorder and their caregivers with a learning health network. The result is an unprecedented system that supports continual advancement in the understanding of bipolar disorder along with improvements in care.

Our Approach icon

Our Approach

The BD² Integrated Network works to improve the health and well-being of people living with bipolar disorder by engaging a network of collaborating investigators and clinicians to:

  • implement and inform data-driven improvements in care
  • build an unprecedented data ecosystem comprised of longitudinal clinical and biological data
  • generate novel insights that will drive innovative approaches to bipolar disorder interventions and treatments
Project Outcomes icon

Project Outcomes

Today, it is estimated that it takes an average of 17 years to translate a scientific discovery to meaningful interventions for people with bipolar disorder.

The BD² Integrated Network aims to collapse that timeline so individuals participating in the network can benefit from better care, today. And more broadly, the network will be able to develop improved care guidelines for all.


Who’s Involved icon

Who’s Involved

The network consolidates the expertise of bipolar disorder clinicians and researchers into a collaborative initiative that will advance clinical care and lead to better outcomes for those living with bipolar disorder.

The inaugural six sites each have the capacity for significant participant enrollment in the longitudinal study and demonstrate a commitment to BD²’s mission of equitable healthcare and meaningful ethnic and racial representation in clinical trials and research studies alongside proven track records of contribution to multi-site initiatives and longitudinal studies.

Key Partners

BD² has partnered with institutions and companies that bring together data, samples, processes, and analysis for the Integrated Network. Their tools and expertise are essential to a functional model.

  • Clinical Coordinating Center - The Feinstein Institutes for Medical Research

    The Clinical Coordinating Center will help to improve bipolar care protocols across the field. The Feinstein Institutes for Medical Research will coordinate with our partner sites and the Data Coordinating Center to ensure the standardization of clinical assessments across sites. These assessments will provide our network with ongoing insight into the individual differences in bipolar disorder in over 4,000 participants across up to 15 clinical sites over the next decade.

    Anil Malhotra, MD
    The Feinstein Institutes for Medical Research
  • Data Coordinating Center - Indoc Research

    The Data Coordinating Center will provide the BD2 Integrated Network with the environments, tools, and processes necessary to maximize the utility of standardized data collected by the participating sites, enabling data aggregation, curation, sharing, and analysis. Indoc’s track record of multi-site coordination positions the network for unprecedented data access and analysis. The centralized approach will power greater scientific understanding of trends and patterns that contribute to the complexity of bipolar disorder and lead to breakthroughs in treatment and care.

    Mojib Javadi, PhD
    Indoc Research

Read Our Concept Brief

The BD2 Integrated Network concept brief provides an in-depth review of our groundbreaking model.

See All BD2 Grantees

Learn more about our Brain Omics Platform, Genetics Platform, and Discovery Research – and the teams that power the work.

Explore Our Work

Learn how BD² will close a fundamental gap in understanding the genetic and biological mechanisms of bipolar disorder.