Grant Year: 2023

Investigating the mitochondrial-related genes, metabolic changes, and the central importance of energy- and activity-related symptoms at the onset of bipolar-related episodes to expand foundational knowledge about bipolar disorder biology and translate that into pharmacological therapeutics and behavioral interventions.

Increasing our understanding of drug action and the pathophysiology of bipolar disorder to provide better insight on mechanisms of action in current treatments, improve upon the use of current treatments, and develop better alternatives.

Delineating causal mechanisms of bipolar disorder using scalable multiomic profiling and genome engineering in patient-derived neuron models.

Providing a more complete picture of the biological mechanisms underlying bipolar disorder, especially those involved in sleep and mania-like behaviors. This could guide therapeutic development by linking genetic changes to circuit and behavioral level impacts.